Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IκBα Degradation
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چکیده
منابع مشابه
The Proteasome Inhibitor PS-341 (Bortezomib) Induces Calpain-dependent IB Degradation
Chunyang Li, Shuzhen Chen, Ping Yue, Xingming Deng, Sagar Lonial, Fadlo R. Khuri, and Shi-Yong Sun From the Departments of Hematology and Medical Oncology and Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia Running title: Proteasome inhibition-induced IB degradation
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198 words; Text4628 words Blood First Edition Paper, prepublished online June 24, 2004; DOI 10.1182/blood-2004-02-0547 Copyright (c) 2004 American Society of Hematology only. For personal use at PENN STATE UNIVERSITY on February 23, 2013. bloodjournal.hematologylibrary.org From
متن کاملDevelopment of the proteasome inhibitor PS-341.
Over the last decade, the critical role of the proteasome in cell-cycle regulation has become increasingly apparent. The proteasome, a multicatalytic protease present in all eukaryotic cells, is the primary component of the protein degradation pathway of the cell. By degrading regulatory proteins (or their inhibitors), the proteasome serves as a central conduit for many cellular regulatory sign...
متن کاملPhase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors.
PURPOSE This phase II study was undertaken to assess objective response, toxicity, tumor marker response, and pharmacodynamics of bortezomib in patients with metastatic neuroendocrine (carcinoid and islet cell) tumors. EXPERIMENTAL DESIGN A total of 16 patients with measurable metastatic carcinoid (n=12) or islet cell (n=4) tumors received i.v. bolus of single agent bortezomib at a dose of 1....
متن کاملProteasome inhibitor bortezomib (PS-341) enhances RANKL-induced MDA-MB-231 breast cancer cell migration.
The receptor activator of nuclear factor κB ligand/receptor activator of nuclear factor κB (RANKL/RANK) pathway is crucial for the migration of RANK-expressing cancer cells. The ubiquitin-proteasome protein degradation pathway plays a significant role in tumor metastasis. However, the relationship between these two pathways in tumor cell migration is unclear. In the present study, we explored t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.072694